Bexarotene

RXR激动剂（在报告试验中，RXRα、RXRβ和RXRγ的EC50s分别为28、25和20nM）；对RXR的选择性优于RAR（RAR；RXRα、RXRβ和RXRγ的EC50s=>10µM）；在10µM时诱导MJ、HuT78和HHCTCL细胞凋亡；在每天100mg/kg的剂量下抑制A549和MDA-MB-231小鼠异种移植模型中的肺转移和血管生成；降低感染SARS-CoV-2的VeroE6细胞培养上清液中的病毒载量（EC90=9.4µM）并在斑块减少试验中抑制SARS-CoV-2复制（EC50=2.01µM）An RXR agonist (EC50s = 28, 25, and 20 nM for RXRα, RXRβ, and RXRγ, respectively, in reporter assays); selective for RXRs over RARs (RARs; EC50s = >10 µM for RXRα, RXRβ, and RXRγ); induces apoptosis in MJ, HuT 78, and HH CTCL cells at 10 µM; inhibits lung metastasis and angiogenesis in A549 and MDA-MB-231 mouse xenograft models at 100 mg/kg per day; reduces viral load in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC90 = 9.4 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 2.01 µM).