HMGB1 Polyclonal Antibody (aa

抗原：人HMGB1氨基酸100-150；宿主：兔；交叉反应：(+)人、牛、鸡、小鼠、新世界猴和大鼠HMGB1；应用：FC、IHC（石蜡包埋组织）和WB；HMGB1是无菌和感染相关反应期间炎症的必要和充分介质。HMGB1还充当DNA核结合蛋白，已证明其通过激活Toll样受体4(TLR4)和晚期糖基化终产物受体(RAGE)成为创伤出血动物模型中无菌炎症的早期触发因素。Antigen: human HMGB1 amino acids 100-150; Host: rabbit; Cross Reactivity: (+) human, bovine, chicken, mouse, New World monkey, and rat HMGB1; Applications: FC, IHC (paraffin-embedded tissue), and WB; HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).