Clioquinol

一种具有神经保护特性的金属螯合抗菌剂；抑制烟曲霉的生长（在不含金属、铁、锌和铜的培养基中，MIC值分别为1、>32、8和16µg/ml）；在37mg/kg剂量下，可减少SNc中的神经元丢失，并增加帕金森病α-突触核蛋白hA53T转基因小鼠模型中Y型迷宫新臂中停留的时间；减少脑萎缩和铁含量，增加黑质酪氨酸羟化酶磷酸化，并挽救tau基因敲除小鼠在转棒和Y型迷宫测试中的行为障碍A metal-chelating antimicrobial agent with neuroprotective properties; inhibits the growth of A. fumigatus (MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively); decreases neuronal loss in the SNc and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson's disease at 37 mg/kg; reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.