β-Catenin (Phospho-Ser33,37) P

抗原：对应于人β-catenin磷酸化Ser33,37周围氨基酸残基的磷酸肽；宿主：兔；交叉反应性：(+)人β-catenin；应用：WB；β-catenin是钙粘蛋白细胞粘附复合物的核心成分，在Wingless/Wnt信号通路中对神经发育起着重要作用。它被认为受GSK3β对Ser29、Ser33、Ser37和Thr41的顺序磷酸化调控。这种过度磷酸化促进了β-catenin的泛素化和靶向破坏。Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human β-catenin; Host: rabbit; Cross-reactivity: (+) human β-catenin; Application: WB; β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway. It is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by GSK3β. This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin.