PPARα Transcription Factor Ass

PPARs是配体激活的转录因子，属于核受体的大超家族。PPARα主要激活编码参与脂肪酸氧化的蛋白质的基因，而PPARγ主要激活直接参与脂肪生成途径和胰岛素信号传导的基因。PPAR家族成员是许多抗糖尿病和降脂药物的重要直接靶标。Cayman的PPAR转录因子测定是一种非放射性、敏感的方法，用于检测核提取物和全细胞裂解物中特定转录因子DNA结合活性。PPARs are ligand-activated transcription factors belonging to the large superfamily of nuclear receptors. PPARα primarily activates genes encoding proteins involved in fatty acid oxidation, while PPARγ primarily activates genes directly involved in lipogenic pathway and insulin signalling. Members of the PPAR family are important direct targets of many antidiabetic and hypolipidemic drugs. Cayman's PPAR Transcription Factor Assays are a non-radioactive, sensitive method for detecting specific transcription factor DNA binding activity in nuclear extracts and whole cell lysates.