TOFA

一种非细胞毒性的ACC和脂肪酸合成抑制剂；在约1µg/ml浓度下，阻止放射标记的醋酸盐合并到棕榈酸中；降低丙二酰辅酶A（malonyl-CoA）水平；对多种癌细胞系相对无毒；减弱FASN抑制剂（如Cerulenin和C75）给药时，观察到的肥胖ob/ob小鼠的进食抑制效应。A non-cytotoxic inhibitor of ACC and fatty acid synthesis; blocks the incorporation of radiolabeled acetate into palmitate at ~1 µg/ml; reduces malonyl-CoA levels; relatively non-toxic to various cancer cell lines; attenuates the inhibition of feeding observed when FASN inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.