Anti-ADAMTS4 Polyclonal Antibo

产品简介

单位	支
英文名称	Anti-ADAMTS4 Polyclonal Antibody
别名	ADAMTS4;ADAMTS-2;ADAMTS-4;ADMP-1
中文名称	凝血酶素基序4的崩解素和金属蛋白酶抗体
宿主	Rabbit
稀释比例	WB 1:500-2000. IHC 1:50-200.
Gene ID	9507
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	O75173
蛋白分子量	90kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Secreted Extracellular matrix Extracellular space
免疫原	Recombinant protein of human ADAMTS4
亚型	IgG
纯化方法	Affinity purification
背景资料	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IF
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Western blot analysis with ADAMTS4 antibody diluted at 1:1000;Lane:C6,Mouse liver,Mouse testis,Mouse brain,Rat brain

Immunofluorescence analysis of SH-SY5Y cells using ADAMTS4 antibody diluted at 1:100.