【FABP4 His】重组人脂肪酸结合蛋白-4，His标签/

产品名称：【FABP4 His】重组人脂肪酸结合蛋白-4，His标签-Recombinant Human Fatty Acid Binding Protein-4， His Tag

产品货号：PRO-566

产品规格：1mg///25ug///5ug

来源宿主：大肠杆菌中重组表达

保存建议：【FABP4 His】重组人脂肪酸结合蛋白-4，His标签-Recombinant Human Fatty Acid Binding Protein-4， His Tag Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Please avoid freeze thaw cycles.

背景资料：Adipocyte fatty acid binding protein FABP4 is a 15 kDa member of the intracellular fatty acid binding protein （FABP） family， which is known for the ability to bind fatty acids and related compounds （bile acids or retinoids） in an internal cavity. FABP4 is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells.In mice， targeted mutations in FABP4 provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from FABP4-deficient mice also have reduced efficiency of ipolysis in vitro and in vivo， and these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated FABP4 expression in macrophages upon differentiation and activation. In these cells， FABP4 modulates inflammatory responses and cholesterol ester accumulation， and total or macrophage-specific FABP4 deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for FABP4 in the development of major components of the metabolic syndrome through its distinct actions in adipocytes and macrophages.

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以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产。其独有细菌和哺乳动物表达和蛋白折叠技术使其成为闻名中外科研级蛋白供应商。ProSpec-Tany是海内上能提供蛋白种类很多公司之一。领先生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。作为多家知名品牌代理，艾美捷与ProSpec一起为研究者们提供优质、全新细胞生物学研究工具而不断扩大产品及服务质量。

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关键词：Recombinant Human Fatty Acid Binding Protein-4， His Tag，【FABP4 His】重组人脂肪酸结合蛋白-4，His标签，FABP4