【Ferritin】人肝铁蛋白/【Ferritin】人肝铁蛋

产品名称：【Ferritin】人肝铁蛋白-Human Liver Ferritin

产品货号：PRO-564

产品规格：10mg///1mg///200ug

来源宿主：人肝脏组织中提取纯化

保存建议：【Ferritin】人肝铁蛋白-Human Liver FerritinHuman Ferritin should be stored at 2-8℃.

背景资料：Ferritin is the main intracellular iron storage protein in prokaryotes and eukaryotes. Ferritin’s major functions are the storage of iron in a soluble and nontoxic state and its release in a controlled fashion. An iron-containing protein complex is found mostly in the intestinal mucosa， spleen， and liver. Ferritin is composed of 24 subunits of the heavy and light chains. Variation in ferritin subunit composition may influence the rates of iron uptake and release in different tissues. Defects in the light chain ferritin gene are linked to a number of neurodegenerative diseases and hyperferritinemia-cataract syndrome. The genes that encode the light and heavy chains are on located different chromosomes. The light chain genes are in chromosome region 19q13.3-q13.4 whilst those for the heavy chain are in chromosome region 11q12-q13. Ferritin is shaped like a hollow sphere， inside which the iron is stored in the Fe（III） oxidation state. The iron is integrated in the mineral ferrihydrite， [FeO（OH）]8[FeO（H2PO4）]， which is attached to the inner wall of the sphere. To release iron once the body needs it， the iron must be altered from the Fe（III） to the Fe（II） oxidation state. Subsequently， the iron leaves through channels in the spherical structure. Therefore， the structure of ferritin is tremendously important for the protein’s ability to store and release iron in a controlled mode.The amount of ferritin in the blood （serum ferritin level） is directly related to the amount of iron stored in the body. The body has a "buffer" against iron deficiency （if the blood has too little iron， ferritin can release more） and， to a lesser extent， iron overload （if the blood and tissues of the body have too much iron， ferritin can help store the excess iron）.

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以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产。其独有细菌和哺乳动物表达和蛋白折叠技术使其成为闻名中外科研级蛋白供应商。ProSpec-Tany是海内上能提供蛋白种类很多公司之一。领先生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。作为多家知名品牌代理，艾美捷与ProSpec一起为研究者们提供优质、全新细胞生物学研究工具而不断扩大产品及服务质量。

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关键词：Human Liver Ferritin，【Ferritin】人肝铁蛋白，Ferritin