产品货号:PRO-444
产品规格:1mg///20ug///5ug
来源宿主:昆虫Sf9细胞中重组表达
保存建议:【PM/Scl 100】重组人PM/Scl100蛋白-Recombinant Human PM/Scl 100Store at 4℃ if entire vial will be used within 2-4 weeks.Store, frozen at -20℃ for longer periods of time.Avoid multiple freeze-thaw cycles.
背景资料:PM/Scl 100 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes).Autoantibodies against PM/Scl 100 occur in patients suffering from polymyositis, scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex (PM/Scl 75, several Rrp proteins) can be found in some sera, practically all patients with autoantibodies against the PM/Scl complex are positive for PM/Scl 100 antibodies, making this specificity an important marker. The presence of PM/Scl 100 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis seen when other myositis and systemic sclerosis specific autoantibodies are present.
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关键词:Recombinant Human PM/Scl 100,【PM/Scl 100】重组人PM/Scl100蛋白,EXOSC10