【Tissue Factor】重组人凝血因子III/【Tis

产品名称：【Tissue Factor】重组人凝血因子III-Recombinant Human Coagulation Factor III

产品货号：PRO-312

产品规格：10ug///1mg///2ug

来源宿主：大肠杆菌中重组表达

保存建议：【Tissue Factor】重组人凝血因子III-Recombinant Human Coagulation Factor IIIStore at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Please avoid freeze thaw cycles.

背景资料：Tissue factor is well-known as the main cellular initiator of blood coagulation. The Tissue factor gene encodes coagulation factor III which is a cell surface glycoprotein that enables cells to initiate the blood coagulation cascades， and functions as the high-affinity receptor for the coagulation factor VII. Following vessel injury， the Tissue Factor and Factor VIIa complex activates the coagulation protease cascade， which leads to fibrin deposition and activation of platelets. The ensuing complex presents a catalytic event， which is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Therefore， Tissue factor has a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Tissue Factor can also be stimulated by the inflammatory mediators interleukin 1 and TNF， as well as by endotoxin， to appear on monocytes and vascular endothelial cells as a component of cellular immune response.Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not been described. Certain levels of Tissue Factor are essential for the maintained viability and growth of endothelium and Tissue Factor-expressing tumor cells. Additionally， abnormal Tissue Factor expression inside the vasculature initiates life threatening thrombosis in various diseases， for example sepsis， atherosclerosis， and cancer. Alternative spliced Tissue Factor expression advances tumor growth， and is linked to increased tumor cell proliferation and angiogenesis in pancreatic cancer.

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关键词：Recombinant Human Coagulation Factor III，【Tissue Factor】重组人凝血因子III，F3