产品货号:PKA-335
产品规格:1ug///50ug///5ug
来源宿主:Sf9昆虫细胞中重组表达
保存建议:【EGFR Sf9】重组人表皮生长因子受体-Sf9(ErbB1),活性-Recombinant Human Epidermal Growth Factor Receptor-Sf9 (ErbB1), Active人表皮生长因子受体-Sf9(ErbB1),活性(EGFR Sf9)溶液可以在-20℃到-80℃温度下冻存用于长期保存,保质期为12月.建议分装以避免反复冻融.
背景资料:The epidermal growth factor receptor (EGF R) subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER1, ErbB1 or ErbB), ErbB2 (Neu, HER-2), ErbB3 (HER-3), and ErbB4 (HER-4). All family members are type I transmembrane glycoprotein that has an extracellular domain which contains two cysteine-rich domains separated by a spacer region that is involved in ligand-binding, and a cytoplasmic domain which has a membrane-proximal tyrosine kinase domain and a C-terminal tail with multiple tyrosine autophosphorylation sites. The human EGF R gene encodes a 1210 amino acid (aa) residue precursor with a 24 aa putative signal peptide, a 621 aa extracellular domain, a 23 aa transmembrane domain, and a 542 aa cytoplasmic domain. EGF R has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF-? , betacellulin, epiregulin, heparin-binding EGF and neuregulin-2 in the absence of a co-receptor. Ligand binding induces EGF R homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGF R can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGF R signaling has been shown to regulate multiple biological functions including cell proliferation, differentiation, motility and apoptosis. In addition, EGF R signaling has also been shown to play a role in carcinogenesis.
点击:【EGFR Sf9】重组人表皮生长因子受体-Sf9(ErbB1),活性-Recombinant Human Epidermal Growth Factor Receptor-Sf9 (ErbB1), Active查看更详细产品说明,更多应用、储存、价格、货期等信息请致电垂询Prospec中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看每日生物评论网站。
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关键词:Recombinant Human Epidermal Growth Factor Receptor-Sf9 (ErbB1), Active,【EGFR Sf9】重组人表皮生长因子受体-Sf9(ErbB1),活性,EGFR Sf9