【FGFR1】重组人成纤维细胞生长因子受体-1/【FGFR1

产品名称：【FGFR1】重组人成纤维细胞生长因子受体-1-Recombinant Human Fibroblast Growth Factor Receptor-1

产品货号：PKA-230

产品规格：10ug///1mg///2ug

来源宿主：昆虫细胞中重组表达

保存建议：【FGFR1】重组人成纤维细胞生长因子受体-1-Recombinant Human Fibroblast Growth Factor Receptor-1人成纤维细胞生长因子受体-1（FGFR1）冻干粉末在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天以上；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-18℃冻存.请避免反复冻融.

背景资料：Fibroblast Growth Factors （FGFs） comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes， including cell growth， differentation， angiogenesis， wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors， FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains， referred to as the alpha isoform， or only IgII and IgIII， referred to as the ? isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3， involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons， generate FGF receptors with alternative IgIII domains （IIIb and IIIc）. A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.

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关键词：Recombinant Human Fibroblast Growth Factor Receptor-1，【FGFR1】重组人成纤维细胞生长因子受体-1，FGFR1