产品货号:ENZ-508
产品规格:10ug///1mg///2ug
来源宿主:HEK293人胚肾上皮细胞中重组表达
保存建议:【TIMP1 HEK】重组人组织基质金属蛋白酶抑制剂1,HEK表达-Recombinant Human Tissue Inhibitor of Metalloprotease 1, HEK人组织基质金属蛋白酶抑制剂1,HEK表达(TIMP1 HEK)冻干粉末在室温可保存3周,或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天;如果想延长保存时间,建议分装(加载体蛋白如0.1% HSA或 BSA)后置于-18℃冻存.请避免反复冻融.
背景资料:TIMP1 is a member of the TIMP family. TIMP1 is an inducible glycoprotein produced by various cell types. The TIMP1 glycoprotein is a natural inhibitor of the matrix metalloproteinases, which a group of peptidases involved in degradation of the extracellular matrix. TIMP1 binds in a reversible mode to MMPs, with regions in the N-terminal domain binding to the MMP substrate-binding site. On top of its inhibitory function against most of the known MMPs, TIMP1 is able to promote cell proliferation in a broad range of cell types, and may also have an anti-apoptotic role. Furthermore, TIMP1 has erthyroid-potentiating activity via translocation to the nucleus and also inhibits apoptosis in B-cells. The TIMP1 gene is situated within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 activity is dependent on the existence of disulfide bonds. TIMP1 transcription is extremely inducible in reaction to many cytokines and hormones. Increased TIMP1 levels are connecte
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关键词:Recombinant Human Tissue Inhibitor of Metalloprotease 1, HEK,【TIMP1 HEK】重组人组织基质金属蛋白酶抑制剂1,HEK表达,TIMP1 HEK