产品名称:p53核转运分析试剂盒/p53核转运分析试剂盒/p53核转运分析试剂盒-p53 Nuclear Translocation Assay Kit /p53 Nuclear Translocation Assay Kit /p53 Nuclear Translocation Assay Kit
产品货号:K961-50
产品规格:50assays
背景资料:待更新
保存建议:p53核转运分析试剂盒/p53核转运分析试剂盒/p53核转运分析试剂盒-p53 Nuclear Translocation Assay Kit /p53 Nuclear Translocation Assay Kit /p53 Nuclear Translocation Assay Kit -20°C
产品描述:p53 is a tumor suppressor gene which encodes a transcription factor that controls cell’s destiny. This gene gets activated when cells are exposed to increased cellular stress, or DNA damage. The levels of p53 are elevated when post-translational modifications occur, which block its sequestration and/or ubiquitination by its destabilizer, Mouse Double Minute 2 Homolog (MDM2) which in turn is a transcriptional target of p53. Due to the three putative nuclear localization signals (NLSs) on its C-terminus, some of the activated p53 protein translocates into the nucleus and activate genes that induce cell cycle arrest, senescence, or apoptosis. The p53 gene is frequently mutated in cancer cells, and about 50% of cancers show p53 mutations, resulting in loss of its functions. The loss of p53 functionality can lead to dysregulation of many biological processes in cells, such as metabolic pathways, cellular homeostasis, cell movement, apoptosis, etc. BioVision’s p53 Nuclear Translocation Assay Kit (Cell-Based) provides an easy and complete assay kit to visualize the activation and nuclear translocation of p53 in human cells. This assay kit uses BioVision’s specific and sensitive human p53 antibody and a p53 secondary antibody to visualize the localization of p53 in fixed common human cells along with DAPI, a fluorescent stain, for nuclear staining. The kit includes Nutlin-3, a potent selective inhibitor that disrupts the protein-protein interaction between p53 and MDM2. Nutlin-3 serves as a control to induce p53 translocation from the cytoplasm to the nucleus
点击:p53核转运分析试剂盒/p53核转运分析试剂盒/p53核转运分析试剂盒-p53 Nuclear Translocation Assay Kit /p53 Nuclear Translocation Assay Kit /p53 Nuclear Translocation Assay Kit 查看更详细产品说明,更多应用、储存、价格、货期等信息请致电垂询BioVision中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看每日生物评论网站。
BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的领路人.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理,艾美捷与BioVision一起为研究者们提供最好、崭新的细胞生物学研究工具而不断扩大产品及服务质量.
艾美捷科技有限公司,通过提供完整的产品和服务体系、便利的客户关系和供应链管理,为生命科学研究工作者提供整体打包方案。我们的企业的核心价值观:“激情、敬业、学习、创新、合作、卓越”。激发我们内在的创造力,提供有竞争力的生物医学产品和服务,持续为客户创造最大价值是我们的企业使命。我们的企业愿景是成为受人尊重、世界知名的生物医学产品及服务供应商。艾美捷科技与国内外优秀的生物试剂供应商保持着密切的合作关系,目前已成为众多国际知名品牌的中国总代理或一级代理,主要包括:AmyJet、AAT Bioquest、Abnova、Agrisera、Biovision、Biosensis、Cayman Chemical、Caisson Labs、Cytoskeleton、CytoNiChe、Epigentek、Equitech-Bio、Hycult Biotech、Jackson、LifeSensors、ProSpec、Norgen Biotek、Mabtech、Matreya、iRegene、StressMarq、ImmunoReagents、SouthernBiotech、Origene、US Biological、Solis BioDyne等,可以在第一时间为用户提供最前沿的专业资讯、完备的产品及物流服务。艾美捷服务升级,全方位实验服务项目上线啦~
关键词:细胞分析试剂盒,p53核转运分析试剂盒/p53核转运分析试剂盒/p53核转运分析试剂盒,待更新