5-hmC多克隆抗体/5-hmC多克隆抗体/5-hmC多克隆

产品名称：5-hmC多克隆抗体/5-hmC多克隆抗体/5-hmC多克隆抗体-5-hmC polyclonal antibody /5-hmC polyclonal antibody /5-hmC polyclonal antibody

产品货号：6830-50

产品规格：50ul

应用类型：hMeDIP: 2.5 ug/IP， Dot Blot: 1:200， ELISA: 1:500.

保存建议：5-hmC多克隆抗体/5-hmC多克隆抗体/5-hmC多克隆抗体-5-hmC polyclonal antibody /5-hmC polyclonal antibody /5-hmC polyclonal antibody 提供的5-hmC多克隆抗体（兔）产品为无色溶液形式，含有50 ul抗体.该产品浓度为与批次相关，溶解于包含有0.05% （W/V）NaN的PBS缓冲液中.请在收到该5-hmC多克隆抗体（兔）产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

背景资料：5-hydroxymethylcytosine （5-hmC） has been recently discovered in mammalian DNA. This results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially， the 5-hmC bases have been identified in Purkinje neurons， in granule cells and embryonic stem cells where they are present at high levels （up to 0.6% of total nucleotides in Purkinje cells）. A recent report indicates that 5-hmC is abundant in brain tissue， especially in areas that are associated with higher cognitive functions. Preliminary results indicate that 5-hmC may have important roles distinct from 5-mC. Although its precise role has still to be shown， early evidence suggests a few putative mechanisms that could have big implications in epigenetics: 5-hydroxymethylcytosine may well represent a new pathway to demethylate DNA involving a repair mechanism converting 5-hmC to cytosine and， as such open up entirely new perspectives in epigenetic studies Due to the structural similarity between 5-mC and 5-hmC， these bases are experimentally almost indistinguishable. Recent articles demonstrated that the most common approaches （e.g. enzymatic approaches， bisulfite sequencing） do not account for 5-hmC. The development of the affinity-based technologies appears to be the most powerful way to differentially and specifically enrich 5-mC and 5-hmC sequences. The results shown here illustrate the use of this unique rabbit polyclonal antibody against 5-hydroxymethylcytosine that has been fully validated in various technologies.

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