Human CellExp™ TIM-3 / HAVCR2,

产品名称：Human CellExp™TIM-3 / HAVCR2，食蟹猴重组/Human CellExp™TIM-3 / HAVCR2，食蟹猴重组/Human CellExp™TIM-3 / HAVCR2，食蟹猴重组-Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant/Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant/Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant

产品货号：P1391-10

产品规格：10ug

来源宿主：待更新

保存建议：Human CellExp™TIM-3 / HAVCR2，食蟹猴重组/Human CellExp™TIM-3 / HAVCR2，食蟹猴重组/Human CellExp™TIM-3 / HAVCR2，食蟹猴重组-Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant/Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant/Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant-20°C

背景资料：Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

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关键词：Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant/Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant/Human CellExp™ TIM-3 / HAVCR2, Cynomolgus Recombinant，Human CellExp™TIM-3 / HAVCR2，食蟹猴重组/Human CellExp™TIM-3 / HAVCR2，食蟹猴重组/Human CellExp™TIM-3 / HAVCR2，食蟹猴重组，HAVCR2, TIM3, TIMD3, FLJ14428, KIM3