FGR, Active/FGR, Active/FGR, A

产品名称：FGR，活跃/FGR，活跃/FGR，活跃-FGR, Active/FGR, Active/FGR, Active

产品货号：7724-5

产品规格：5ug

来源宿主：提供的【FGR】FGR蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.

保存建议：FGR，活跃/FGR，活跃/FGR，活跃-FGR, Active/FGR, Active/FGR, Active在您收到艾美捷发出的【FGR】FGR蛋白,有活性的产品后，建议将其置于-80°C保存.

背景资料：Fgr is a protooncogene that is a unique member of the tyrosine kinase gene family. It is localized to the distal portion of the short arm of human chromosome 1 at p36.1-36.2 by in situ hybridization (1). Certain lymphomas (but not sarcomas or carcinomas) express fgr-related messenger RNA. This transcript is detected in Burkitt’s lymphoma cell lines naturally infected with Epstein-Barr virus (EBV), but not in EBV-negative Burkitt’s lymphoma cells (2). Normal umbilical cord or peripheral blood lymphocyte lines established in vitro by EBV infection also contain detectable c-fgr mRNA. Moreover, a 50-fold increase of the steady-state c-fgr mRNA concentration is observed when uninfected Burkitt’s lymphoma cell lines are deliberately infected with EBV demonstrating the induction of a proto-oncogene in response to infection by a DNA tumour virus. Fgr expression is limited to normal peripheral blood granulocytes, monocytes, and alveolar macrophages, all of which contain 50 to 100 copies of c-fgr mRNA per cell (3). The c-fgr RNA molecules in these cells consisted of partially spliced transcripts containing intron 7 and completely spliced molecules capable of encoding the predicted p55 c-fgr protein. The level of fgr transcripts begin to increase 2 to 4 h after TPA addition, peak at 8 h, and subsequently declined suggesting transient transcriptional activation of fgr during TPA-induced differentiation. Cycloheximide also causes accumulation of c-fgr transcripts in U937 cells. Thus, c-fgr gene is expressed in a tissue- and development-specific fashion and constitutive expression of c-fgr in U937 cells is regulated by a labile transcriptional repressor.

点击：FGR，活跃/FGR，活跃/FGR，活跃-FGR, Active/FGR, Active/FGR, Active查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询BioVision中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

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关键词：FGR, Active/FGR, Active/FGR, Active，FGR，活跃/FGR，活跃/FGR，活跃，FGR