Anti-Osteopontin /Anti-Osteop

产品名称：骨桥蛋白/骨桥蛋白/骨桥蛋白-Anti-Osteopontin /Anti-Osteopontin /Anti-Osteopontin

产品货号：5421-100-E

产品规格：100ug

应用类型：ELISA - Sandwich and Indirect

保存建议：骨桥蛋白/骨桥蛋白/骨桥蛋白-Anti-Osteopontin /Anti-Osteopontin /Anti-Osteopontin 提供的Osteopontin （克隆号14C08）产品为无色溶液形式，含有100 ug抗体.该产品浓度为1 mg/ml，溶解于0.15 M PBS缓冲液中.请在收到该Osteopontin （克隆号14C08）产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

背景资料：Human Osteopontin （OPN） is a negatively charged hydrophilic protein of 314 amino acids and is subject to significant post translational modifications. OPN is cleaved by members of the matrix metalloproteinase family （MMP） which results in the generation of N-terminal and C-terminal OPN fragments. The matricellular protein osteopontin binds to cell surface receptors and is secreted into many body fluids including milk， blood and urine， depending on the organ of origin. This makes osteopontin an ideal candidate for being a biomarker as the secreted form is easily obtained in throwaway fluids， and mimics the cellular environment from which it is released. Osteopontin is important in immune responses and inflammation as well as bone generation and remodeling. In autistic children， serum levels of osteopontin are correlated to the severity of disease， probably due to a brain inflammation pattern in these children. In aortic valve sclerosis and stenosis， increased levels of secreted osteopontin are also noted. Osteopontin has also been suggested as a cancer biomarker， since it is associated with tumor formation， progression and metastasis. In bone and tooth formation osteopontin is known to be a negative regulator of parathyroid hormone-related protein receptor， which induces osteogenesis. Without appropriate levels of osteopontin， bone growth continues unregulated， and leads to specific bone cancers. In short， osteopontin is a strong marker for bone growth， inflammation and certain cancers. The newly exposed SVVYG epitope on the N-terminal fragment has also been shown to participate in cell adhesion.

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关键词：Anti-Osteopontin /Anti-Osteopontin /Anti-Osteopontin ，骨桥蛋白/骨桥蛋白/骨桥蛋白，Osteopontin