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mAB-O | Mouse anti-human Abeta

protein (3-10) region, oligomer-specific (clone 3E5.F8)
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  • 询价
  • Agrisera
  • 瑞典
  • AS13 2715
  • 2026年03月18日
  • 10 ug/ml (IL), 1-2 ug/ml (Dot), 1 ug/ml (ELISA capture)
  • Mouse
  • Human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide chosen from human Abeta (1-42) protein.

    • 亚型

      IgG1, kappa light chain, (clone number 3E5.F8)

    • 形态

      Lyophilized

    • 保存条件

      Store lyophilized/reconstituted at -20°C; once rec

    • 克隆性

      Monoclonal

    • 标记物

      Brännström et al. (2014). A Generic Method for Design of Oligomer-Specific Antibodies. PLoS ONE. DOI: 10.1371/journal.pone.0090857.

    • 适应物种

      Human

    • 级别

      分子生物学级

    • 供应商

      Agrisera

    • 宿主

      Mouse

    • 应用范围

      10 ug/ml (IL), 1-2 ug/ml (Dot), 1 ug/ml (ELISA capture)

    • 靶点

      Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-b

    • 抗体英文名

      Immunolocalization: human tissue was paraffin-embedded and sectioned. De-waxed and rehydrated in an ethanol gradient. Antigens were retrieved in sodium citrate buffer (pH 6) at 95°C for 1 h. The tissue sections were separately incubated for 1 h at RT with

    • 抗体名

      mAB-O | Mouse anti-human Abeta protein (3-10) region, oligomer-specific (clone 3E5.F8)

    • 规格

      50 µg

    Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of the amyloid precursor protein. Recent findings however suggest that smaller oligomeric forms of Abeta, formed in parallel to the amyloid plaques, excert the predominant tissue damaging effect.Specific identification of the oligomeric forms is as a consequence of great interest. Based on a recently published technique a highly oligomer-specific antibody (mAB-O), targeting Abeta oligomers while omitting reactivity towards the monomeric and fibrillar counterpart, has been developed.

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    图标文献和实验
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    mAB-O | Mouse anti-human Abeta protein (3-10) region, oligomer-specific (clone 3E5.F8)
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