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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
human C1 Inhibitor CAA30314
- 形态:
Immunogen Affinity purified using solid phase human C1 Inhibitor.
- 保存条件:
Store at 2-8°C.
- 克隆性:
Polyclonal
- 适应物种:
Human C1 Inhibitor
- 供应商:
Agrisera
- 宿主:
Sheep
- 应用范围:
ELISA (ELISA), Immuoassays, Western Blot (WB)
- 靶点:
Anti-C1-inh | C1 Inhibitor
- 抗体英文名:
Anti-C1-inh | C1 Inhibitor
- 抗体名:
Anti-C1-inh | C1 Inhibitor
- 规格:
1 mg
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文献和实验C1-Inhibitor: Antigenic and Functional Analysis
The classical pathway of complement is activated in various diseases. A main inhibitor of this pathway is the serpin C1-inhibitor (C1-Inh), which regulates activation at the level of C1. C1-Inh also inhibits the mannan binding lectin (MBL
C1 Inhibitor: Quantification and Purification
C1 inhibitor is a multipotent serpin capable of inhibiting the classical and the lectin pathways of complement, the fibrinolytic system, and contact/kinin system of coagulation. Deficiency of C1 inhibitor manifest as hereditary angioedema
上有Clr和Cls相互反应的的功能区。反应功能区朝向中心,催化功能区位于外侧。在一般C1INH与C1r结合着,而一旦有免疫复合物结合到Clq时,C1INH的抑制作用即行移除,并通过C1q的胶原性柄将其头部的移动传递到其核心区,并从此处再传递到与其相连接的C1r,诱导C1r构象改变并裂解活化。活化的C1r(C1r),再作用于C1s使之成为活化型C1s(C1s)。 C1r和C1s的cDNA克隆均已成功,并进行了全部序列分析。编码C1r的基因定位于人的第12号染色体短臂13-ter,与编码
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