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- 2025年07月05日
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- 文献和实验
- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 英文名：
BIA 5-453 hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥6280.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1920.0 |
| 规格： | 5 mg | 产品价格： | ￥4800.0 |
| 规格： | 10 mg | 产品价格： | ￥8000.0 |
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Etamicastat hydrochloride
CAS No. : 677773-32-9
MCE 国际站：Etamicastat hydrochloride
产品活性：Etamicastat hydrochloride (BIA 5-453 hydrochloride) 是一种有效且可逆的多巴胺 β-羟化酶 (DBH) 抑制剂，IC50 值为 107 nM。可用于心血管疾病的研究。
研究领域：Metabolic Enzyme/Protease
作用靶点：Dopamine β-hydroxylase
In Vitro: Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL (141 μM).
In Vivo: Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels.
Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.
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文献和实验Guanidine Hydrochloride Purification of Proteins From SDS
Pepstatin A (2.0 mg/ml)10 ml Leupeptin (1.0 mg/ml)10 ml Aprotinin (5.0 mg/ml)(Protease Inhibitor Cocktail Sigma #P8340)Denaturation Buffer6 M guanidine hydrochloride 57.3 g G-HCl20 mM Hepes 7.9 2 ml 1M Hepes pH 7.910 mM KCl 0.074 g KCl0.5 mM DTT 100 ml 0.5 M
Guanidine Hydrochloride Purification of Proteins From SDS PAGE
(Sigma #P7626) 10 ml Pepstatin A (2.0 mg/ml) 10 ml Leupeptin (1.0 mg/ml) 10 ml Aprotinin (5.0 mg/ml) (Protease Inhibitor Cocktail Sigma #P8340) Denaturation Buffer 6 M guanidine hydrochloride 57.3 g G-HCl 20 mM Hepes 7.9 2 ml 1M Hepes pH 7.9 10 mM
Packed column subcritical and/or supercritical fluid chromatography (p-sub or pSFC) has been used as a powerful chiral separation technique, whereby a mobile phase produces low viscosity, a high diffusion coefficient, and a solvating power. P
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