Zetomipzomib

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Zetomipzomib

CAS No. : 1629677-75-3

MCE 国际站：Zetomipzomib

产品活性：Zetomipzomib (KZR-616) 是首创的免疫蛋白酶体 (immunoproteasome) 抑制剂，选择性靶向免疫蛋白酶体亚基 LMP7 (IC₅₀: 39/57 nM=hLMP7/mLMP7) 和 LMP2 (IC₅₀: 131/179 nM=hLMP7/mLMP7)。Zetomipzomib 用于多种自身免疫性疾病的潜力。

研究领域：Metabolic Enzyme/Protease

作用靶点：Proteasome

In Vitro: Zetomipzomib also inhibits MECL-1 subunit (IC₅₀=623 nM) and constitutive proteasome β5 subunit (IC₅₀=688 nM). Zetomipzomib maintains LMP7 and LMP2 selective inhibition in MOLT-4 cells. Zetomipzomib (250 nM) shows a comparable cytokine inhibition profile peripheral blood mononuclear cells (PBMC).Zetomipzomib is an immunoproteasome-selective inhibitor identified based on the optimization of ONX-0914 (HY-13207) and PR-924 (HY-123587).

In Vivo: Zetomipzomib (5 mg/kg; i.v.; dosing was repeated on days 6, 8, 11, and 13) shows efficacy in the anticollagen antibody induced arthritis (CAIA) model.

相关产品：MG-132  |  Bortezomib  |  Carfilzomib  |  Celastrol  |  Ixazomib  |  Epoxomicin  |  Isoginkgetin  |  Calpeptin  |  ONX-0914  |  PD150606  |  MG-101  |  Marizomib  |  Capzimin  |  MDL-28170  |  18α-Glycyrrhetinic acid  |  Oprozomib  |  K-7174 dihydrochloride  |  Aclacinomycin A hydrochloride  |  Delanzomib  |  PD 151746  |  Zetomipzomib maleate  |  Isovalerylcarnitine  |  KZR-504  |  M3258  |  TCH-165  |  RA190  |  Tomatine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds