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- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
1408311-94-3
- 规格:
10 mM * 1 mL/1 mg/5 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥ |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥2200.0 |
| 规格: | 5 mg | 产品价格: | ¥5500.0 |
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(rel)-AR234960
CAS No. : 1408311-94-3
MCE 国际站:(rel)-AR234960
产品活性:(rel)-AR234960 是AR234960 的相对活性构型。AR234960 是一种非肽类的MAS (一种G蛋白的偶联受体) 的激动剂,在HEK293-MAS 细胞和成人心肌成纤维细胞中,通过 ERK1/2 信号通路中上调 CTGF mRNA 和蛋白水平。
研究领域:MAPK/ERK Pathway | Stem Cell/Wnt
作用靶点:ERK
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文献和实验renamed rel A) and p50 (recently renamed NFKB1) ( 3 , 4 ). Both of these sub-units belong to the rel famtly of transcription factors with homology in the amino terminus ( 5 , 6 ). Since the original identification of these factors
A Method for Isolating Prosurvival Targets of NF-B/Rel Transcription Factors
NF-κB/Rel transcription factors are critical regulators of immunity, inflammation, development, and cell survival. Activation of NF-κB inhibits programmed cell death (PCD) triggered by tumor necrosis factor α (TNF
陈有海团队 Nature Cancer 报道髓系细胞检查点,会是癌症免疫治疗下一个热点吗?
,MDSCs 的缺失可显著增强小鼠的抗肿瘤免疫。然而,是否存在可以靶向治疗癌症的髓系细胞检查点,至今尚不明确。图片来源:Nature Cancer2020 年 5 月 18 日,宾夕法尼亚大学佩医学院的陈有海团队在 Nature Cancer 上在线发表了题为 c-Rel is a myeloid checkpoint for cancer immunotherapy 的研究成果。该研究发现 c-Rel 是诱导 MDSCs 分化进而促进癌症发展的关键因子,同时阻断 c-Rel 和淋巴检查点 PD1 在治疗
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