D-erythro-Sphingosine, D9/D-er

产品名称：D-赤型-神经鞘氨醇-D-erythro-Sphingosine, D9

产品货号：2079-1

产品规格：1mg

背景资料：固体

保存建议：D-赤型-神经鞘氨醇-D-erythro-Sphingosine, D9对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：This synthetic D-erythro-sphingosine contains nine deuterium atoms making it an ideal stable isotope-labeled standard for lipidomic studies using mass spectrometry. Stable isotope-labeled tracers are ideal for studies involving the metabolism and various metabolites of a lipid and can be used for the quantitative evaluation of major lipid pathways.1 Lipidomics has shown great success in the use of deuterium labeled compounds in identifying and quantifying individual molecular species by the use of tandem mass spectrometry.2 This deuterated sphingosine can also be used in the preparation of sphingolipids that are labeled on the sphingosine chain. In this way deuterated ceramides can be prepared that will not lose their label if the fatty acid is cleaved off in vivo and replaced by an alternate fatty acid. Sphingosine is a characteristic structural unit of many sphingolipids such as ceramides, gangliosides, globosides, sulfatides, sphingomyelin, and others.3,4 It is most abundant in nervous tissue and cell membranes. Sphingosine with an 18- carbon chain and a double bond at carbon 4 is the most abundant sphingosine in animal tissues. Lysosphingolipids inhibit protein kinase C activity resulting in the pathogenesis of sphingolipidoses such as Krabbe's disease and Gaucher's disease.5 Sphingosine can be phosphorylated via two kinases to form sphingosine-1-phosphate, which has important signaling functions. While sphingosines and ceramides can induce apoptosis,6 sphingosine-1-phosphate can promote cell survival or proliferation. Sphingosine has also been shown to cause an increase in the cytoplasmic calcium level of cells.

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关键词：生化试剂，D-赤型-神经鞘氨醇，待更新