N-Hexanoyl-NBD-glucosylceramid

产品名称：N-己酰基-NBD-葡萄糖基神经酰胺-N-Hexanoyl-NBD-glucosylceramide

产品货号：1622-1

产品规格：1mg

背景资料：固体

保存建议：N-己酰基-NBD-葡萄糖基神经酰胺-N-Hexanoyl-NBD-glucosylceramide对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：This high purity fluorescent product is ideal for the identification of glucocerebrosides in samples and biological systems.1 7-nitrobenzofurazan (NBD) has been shown to have only a small influence on lipid adsorption into cells and cellular membranes. This fluorescent analog of natural glucosylceramide is comparable to C6:0-glucosylceramide in many biological functions.2 This cerebroside product is a glycosphingolipid containing a glucose attached to a ceramide (glucocerebroside) acylated with a C6:0-NBD fatty acid. Glucosylceramide is a major constituent of skin lipids where it has an important role in lamellar body formation and in maintaining the water permeability barrier. Glucocerebroside is very important due to its function as the biosynthetic precursor of lactosylceramide and from there of most of the neutral oligoglycolipids and gangliosides. Glucocerebroside is the only glycosphingolipid that is found in plants, fungi, and animals and is one of the most abundant glycosphingolipids in plants. Due to the relatively high melting point of cerebrosides (much greater than physiological body temperature) they have a para-crystalline structure. Glucocerebrosides tend to be concentrated in the outer leaflet of the plasma membrane in lipid rafts. It has been reported that glucocerebrosides are essential for the activity of tyrosinase (a key enzyme in melanin biosynthesis), to elicit defense responses in plants, and to help the plasma membrane in plants to withstand stresses brought about by cold and drought. In Gaucher’s disease glucocerebrosides accumulate in the spleen, liver, lungs, bone marrow, and brain due to a deficiency of the enzyme glucocerebrosidase.3 This accumulation of glucocerebroside has been associated with chemotherapy resistance. Glucocerebroside has been shown to be able to modulate membrane traffic along the endocytic pathway.4

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关键词：生化试剂，N-己酰基-NBD-葡萄糖基神经酰胺，待更新