Cyclin C Antibody (Boster Biological Technology, Wuhan, China. Catalog #A05832-1)
应用范围
WB
抗体来源
Rabbit
免疫原
A peptide derived from human Cyclin C. Immunogen sequence location: 234-283
抗体规格
100ug/vial
产品详情
克隆
Polyclonal
产品形态
Liquid
内容
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. *可以提供无载体抗体。
储存条件
At -20℃ for one year. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for a longer time.Avoid repeated freezing and thawing.
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. .
Tissue Specificity
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.