背景资料 |
CD86 is officially called Cluster of Differentiation 86, also known as B7-2. Being a member of the immunoglobulin superfamily, it is a protein expressed on antigen-presenting cells. The CD86 gene is mapped to human chromosome 3q21. The smallest transcript, 828 bp, which the authors termed CD86deltaTM, has a deletion from nucleotide 686 to nucleotide 829(i.e., exon 6) and encodes a 275-amino acid protein. CD86deltaTM enhances proliferation and cytokine production by both naive and memory T cells, providing costimulatory signals necessary for T cell activation and survival. |
研究类别 |
1. Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726. 2. Freeman, G. J., Gribben, J. G., Boussiotis, V. A., Ng, J. W., Restivo, V. A., Lombard, L. A., Gray, G. S., Nadler, L. M.Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.Science262: 909-911, 1993.3. Jellis, C. L., Wang, S. S., Rennert, P., Borriello, F., Sharpe, A. H., Green, N. R., Gray, G. S.Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86).Immunogenetics42: 85-89, 1995. |