Synthesized peptide derived from the Internal region of human Bcl-6.
内容
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化方式
Immunogen affinity purified
浓度
500 ug/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
产品形态
Liquid
保存条件
12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料
B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene. Like BCL2, BCL3, BCL5, BCL7A, BCL9 and BCL10, it has clinical significance in lymphoma. The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain. This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with several corepressor complexes to inhibit transcription. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLBCL) and contributes to the pathogenesis of DLBCL. An exon 7 skipping splice variant encodes a shorter form of the protein which lacks the first two zinc fingers of the DNA binding domain.
研究类别
1. "Entrez Gene: BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51)".2. Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R (October 1993). "Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma". Science. 262 (5134): 747–50. 3. Kerckaert JP, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C (September 1993). "LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas". Nature Genetics. 5 (1): 66–70.4. Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R (December 1995). "Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma". Proceedings of the National Academy of Sciences of the United States of America. 92 (26): 12520–4.
[list_product_images]Western Blot (WB) analysis of 293 cells using Bcl-6 Polyclonal antibody.|Immunohistochemistry (IHC) analysis of paraffin-embedded Human Liver, antibody was diluted at 1:100.|Immunohistochemistry (IHC) analysis of paraffin-embedded Human Liver, antibody was diluted at 1:100.|Immunohistochemistry (IHC) analysis of paraffin-embedded Human Liver, antibody was diluted at 1:100.|Immunohistochemistry (IHC) analysis of paraffin-embedded Human Liver, antibody was diluted at 1:100.[/list_product_images]