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- PEPROTECH
- 315-22
- 美国
- 2025年07月10日
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- 详细信息
- 技术资料
- 供应商：
PeproTech(派普泰克)
- 库存：
大量
- 英文名：
Recombinant Murine Sonic HedgeHog (Shh)
Recombinant Murine Sonic Hedgehog (Shh)
产品编号:
315-22
别名:
Hhg-1
描述:
Members of the Hedgehog (Hh) family are highly conserved proteins which are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh) are structurally related and share a high degree of amino-acid sequence identity (e.g., Shh and Ihh are 93% identical). The biologically active form of Hh molecules is obtained by autocatalytic cleavage of their precursor proteins and corresponds to approximately the N-terminal one half of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can substitute for each other in experimental systems. Recombinant murine Sonic HedgeHog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the naturally occurring chemically modified Cys residue.
氨基酸序列:
IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKITRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG
来源:
E.coli
纯度:
Greater than 90% by SDS-PAGE gel and HPLC analyses.
生物活性:
Determined by its ability to induce alkaline phosphatase production by C3H/10T1/2 (CCL-226) cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
原产国:
USA
仅用于研究。不适用于诊断或治疗。
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PeproTech重组小鼠Sonic HedgeHog (Shh) 5ug
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