Formula: C34H54N8O10S A structure-activity study of the Neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy. potency and affinity at the NK2 receptor in human colon circular muscle. Two series of NKA(4-10) analogues were produced with either L-alanine or the D-enantiomer substituted. Their activities were determined in vitro by means of radioligand binding and isolated smooth muscle pharmacology.
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular Location: Secreted protein.
Similarity: Belongs to the tachykinin family. [1] Wang,Y., Badgery-Parker,T., Lovas,S., Chartrel,N., Vaudry,H., Burcher,E. and Conlon,J.M.
Primary structure and receptor-binding properties of a neurokinin A-related peptide from frog gut [2] Wang Y., Badgery-Parker T., Lovas S., Chartrel N., Vaudry H., Burcher E., Conlon J.M.
Primary structure and receptor-binding properties of a neurokinin A-related peptide from frog gut.