SB-267268,205678-26-8

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SB-267268

CAS No. : 205678-26-8

MCE 国际站：SB-267268

产品活性：SB-267268 是一种选择性和非肽性 αvβ3 和 αvβ5 整合素拮抗剂，对人αvβ3，猴 αvβ3 和 人αvβ5 的 K_i 分别为 0.9，0.5 和 0.7 nM。SB-267268 抑制人和小鼠 αvβ3 的 IC₅₀ 值为 0.68 和 0.29 nM。SB-267268 降低血管生成和 VEGF 表达。

研究领域：Cytoskeleton

作用靶点：Integrin

In Vitro: SB-267268 was much less potent for inhibition of human, mouse, and ratαvβ6 integrin. SB-267268 inhibits the attachment of bothαvβ3-transfected HEK293 cells to microtiter plate wells precoated with arginine-glycine-aspartic acid (RGD)-containing matrix proteins with IC₅₀ values of 12 nM. SB-267268 also inhibits vitronectin-mediated human and rat aortic smooth-muscle-cell (SMC) migration with IC₅₀ values of approximately 12.3 nM and 3.6 nM, respectively.

In Vivo: SB-267268 (60 mg/kg; bi-daily, i.p.) reduces blood vessel profiles (BVPs) in the inner retina by 50%.
In ROP mice treated with SB-267268, VEGF and VEGFR-2 gene expression in the inner nuclear layer (INL) and the ganglion cell layer (GCL) is reduced.

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