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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
130773-02-3
- 规格：
10 mM * 1 mL/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥715.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥650.0 |
| 规格： | 50 mg | 产品价格： | ￥950.0 |
| 规格： | 100 mg | 产品价格： | ￥1600.0 |
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Neticonazole hydrochloride
CAS No. : 130773-02-3
MCE 国际站：Neticonazole hydrochloride
产品活性：Neticonazole hydrochloride 是一种咪唑衍生物，也是一种有效且长效的抗真菌剂。Neticonazole hydrochloride 具有抗感染和抗癌作用。
研究领域：Anti-infection
作用靶点：Fungal
In Vitro: Neticonazole (10 μM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
?Neticonazole (0-10 μM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
?Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor.
In Vivo: Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
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