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- 保存条件：
4°C, sealed storage, away from moisture and light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
18010-40-7
- 规格：
10 mM * 1 mL/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥790.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥600.0 |
| 规格： | 500 mg | 产品价格： | ￥900.0 |
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Bupivacaine hydrochloride
CAS No. : 18010-40-7
MCE 国际站：Bupivacaine hydrochloride
产品活性：Bupivacaine hydrochloride 是一种 NMDA 受体抑制剂。Bupivacaine 可以阻断钠、L-钙和钾通道。Bupivacaine 有效阻断 SCN5A 通道，IC50 为 69.5 μM。Bupivacaine hydrochloride 可用于慢性疼痛的研究。
研究领域：Neuronal Signaling | Membrane Transporter/Ion Channel
作用靶点：iGluR | Sodium Channel | Calcium Channel | Potassium Channel
In Vitro: Bupivacaine hydrochloride inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically involved in central sensitization.
?Bupivacaine hydrochloride influences the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward somewhat more negative membrane potentials. In their inactivated state, SCN5A channels are slightly sensitive toward Bupivacaine hydrochloride IC50=2.18±0.16 μM.
?Bupivacaine hydrochloride reversibly inhibits the SK2 channel in a dose-dependent manner with the IC 50 of 16.5 μM.
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文献和实验剂：200mg/10ml；400mg/20ml。浸润麻醉用0.25%～0.5%溶液，表面麻醉、传导麻醉、硬膜外麻醉均可用1%～2%溶液。一次极量500mg。腰麻不宜超过100mg。 盐酸布比卡因（bupivacaine hydrochloride）注射剂：12.5mg/5ml；25mg/5ml；37.5mg/5ml。浸润麻醉用0.25%溶液，传导麻醉用0.25%～0.5%溶液，硬膜外麻醉用0.5%～0.75%溶液。一次极量200mg,一日极量400mg。
。 盐酸丁卡因（tetracaine hydrochloride）注射剂：50mg/5ml。表面麻醉用0.25%～1%溶液，传导麻醉、腰麻及硬膜外麻醉可用0.2%溶液。腰麻不宜超过16mg。 盐酸利多卡因（lidocaine hydrochloride）注射剂：200mg/10ml；400mg/20ml。浸润麻醉用0.25%～0.5%溶液，表面麻醉、传导麻醉、硬膜外麻醉均可用1%～2%溶液。一次极量500mg。腰麻不宜超过100mg。 盐酸布比卡因（bupivacaine
Nick Translation of DNA for CGH
60 min 3 ul (16 comb) 100-2 kb PCR Amplified Microdissected DNA 40 ul mix 3.0 ul
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