神经酰胺三己糖苷（底部斑点）|Ceramide trihex

神经酰胺三己糖苷（底部斑点），Ceramide trihexosides (bottom spot)，Ceramide trihexosides

产品名称：神经酰胺三己糖苷（底部斑点）-Ceramide trihexosides (bottom spot)

产品货号：1514-500

产品规格：500ug

背景资料：Ceramide trihexoside (CTH) is a glycosphingolipid found mostly in mammalian cell membranes. It is involved in cellular signaling and has been identified as a receptor for various toxins including shiga toxins and shiga-like toxins.1 Some toxins, such as veratoxins from Escherichia coli, require specific fatty acids on the ceramide portion of CTH to show affinity in binding. An accumulation of CTH in the cellular membranes due to a lack of alpha-galactosidase to convert it into lactosyl ceramide results in Fabry disease.2 This product can be used as an excellent standard for the identification of CTH in Fabry disease by HPLC3 and mass spectrometry.4 An inability to convert CTH to globoside due to mutations in the gene sequence leads to the Pk blood group phenotype. It appears that under certain conditions CTH can enhance anticoagulant activity. CTH has also been studied as a tool to investigate lymphocyte activation.5 Neutral glycolipids may help to cause resistance to natural killer cells in some types of cells. Interferon appears to slightly increase the resistance of cells towards natural killer cells and also increases the amounts of non-hydroxylated fatty acids on various glycolipids, suggesting that there may be a connection between the hydroxylated fatty acids and natural killer cell resistance.

保存建议：神经酰胺三己糖苷（底部斑点）-Ceramide trihexosides (bottom spot)对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：CTH with hydroxy fatty acid side chain

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