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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2020052-55-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4400.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1100.0 |
| 规格： | 5 mg | 产品价格： | ￥2740.0 |
| 规格： | 10 mg | 产品价格： | ￥4390.0 |
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CDK12-IN-E9
CAS No. : 2020052-55-3
MCE 国际站：CDK12-IN-E9
产品活性：CDK12-IN-E9 是一种有效的选择性共价 CDK12 抑制剂和非共价 CDK9 抑制剂，同时避免了 ABC 转运蛋白介导的外排。CDK12-IN-E9 对 CDK7/CyclinH 复合物的结合能力较弱，IC50 > 1 μM。
研究领域：Cell Cycle/DNA Damage
作用靶点：CDK
In Vitro: CDK12-IN-E9 (E9; 10 nM-10 μM; 72 hours; Kelly, LAN5, SK-N-BE2, PC-9, NCI-H82 and NCI-H3122 cells) treatment shows potent antiproliferative activity in THZ1R NB and lung cancer cells, with IC50 values ranging from 8 to 40 nM.
CDK12-IN-E9 (E9; 0-3000 nM; 6 hours; Kelly, PC-9, and NCI-H82 cells) treatment leads to a dose-dependent decrease in phosphorylated and total RNAPII in THZ1r NB and lung cancer models, accompanied by decreased MYC and MCL1 expression.
CDK12-IN-E9 also results in increased PARP cleavage, and an increase in the subGI population in THZ1r lung cancer cells, while in NB cells, more of a G2/M arrest is seen after a 24-hr exposure to CDK12-IN-E9.
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文献和实验Wholemount in situ hybridisation
. Each batch should ideally be tested. As a rough guide, use 5 min for E7.5, 7 min for E8.5, 9 min for E9.5, 11 min for E10.5, 12-14 min for E11.5. 8 Wash twice with PBTX for 5 minutes each. Be careful - the embryos are fragile
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PAGE和2D SDS-PAGE区别 多少（PAGE）胶浓度适合分离55和58kd这2种蛋白？ 加样后样品总是沿着样品池两个垂直边缘向上渗透 聚丙烯酰胺凝胶电泳(PAGE) 26 硝酸银染色法 6 SDS agarose gels for analysis of proteins 13 ---------------------------2002---------------------------------------------------------
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