CB1151,182369-28-4

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CB1151

CAS No. : 182369-28-4

MCE 国际站：CB1151

产品活性：CB1151 是 1,25 二羟基维生素D3 (VD) 的 20 表位类似物 ( 20-epi analogue of VD)，具有有效的抗肿瘤作用。CB1151 抑制 MCF-7 细胞生长， IC₅₀ 值为 0.82 nM。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：VD/VDR

In Vitro: CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [³H]-thymidine incorporation, exhibits an IC₅₀ value of 0.82 nM.
CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC₅₀ of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC₅₀=3.2nM) in MCF-7 cells transfected with the CAT reporter.
CB1151 shows a functional dissociation constant (K_df) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by K_df, this is different from that of the traditional dissociation constant (K_d).

相关产品：Bioactive Compound Library Plus  |  Calcitriol  |  Calcipotriol  |  Vitamin D3  |  Calcifediol  |  Tachysterol 3  |  Paricalcitol  |  Vitamin D2  |  Ercalcidiol  |  Alfacalcidol  |  TEI-9647  |  Eldecalcitol  |  Ercalcitriol  |  Secalciferol  |  Seocalcitol  |  MeTC7  |  Maxacalcitol  |  VD3-d6  |  Inecalcitol  |  Tacalcitol  |  Vitamin D4  |  ZK168281  |  Doxercalciferol  |  VD2-d3  |  24, 25-Dihydroxy VD2  |  3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds