Xanthatin

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Xanthatin

CAS No. : 26791-73-1

MCE 国际站：Xanthatin

产品活性：Xanthatin 从 Xanthium strumarium 叶子中提取，诱导细胞凋亡 (apoptosis)。Xanthatin 通过抑制 PGE2 的合成和 5-脂氧合酶的活性而显示出抗炎活性。Xanthatin 抑制布鲁氏菌的 IC₅₀ 值为 2.63 μg/ mL，对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。

研究领域：Apoptosis  |  Protein Tyrosine Kinase/RTK  |  Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Apoptosis  |  VEGFR  |  Lipoxygenase  |  Bacterial

结构分类：萜类  |  倍半萜

来源：植物  |  其他科

In Vitro: Xanthatin is against T. b. brucei with an IC₅₀ value of 2.63 µg/mL and exhibits weak irreversible inhibition of parasite specific trypanothione reductase.
Xanthatin (0-40 μM; 24 hours) has obscure inhibition effect on the proliferation of HUVEC in the absence of VEGF.
Xanthatin (5-40 μM; 24 hours) inhibits breast cancer cell proliferation in a dose responsive manner. Xanthatin inhibits HCC1937, MDA-MB-415, SK-BR-3, MCF-7 and MDA-MB-231 with IC₅₀ values of 81 μM, 31 μM, 38 μM, 30 μM, and 17 μM, respectively.
Xanthatin (0-10 μM; 24 hours) dose dependently suppresses the phosphorylation of STAT3 (Ser727), at the same time, it also results in a rapid dephosphorylation of down-stream kinases of STAT3, including PI3K and Akt, including PI3K (p-PI3K p85 _tyr458) and Akt.

In Vivo: Xanthatin (intragastric administration; 20 mg/kg; once daily; 25 days) leads to significant inhibition of tumor volume. And this compound is well-tolerated and exhibits no significant difference in weight compares to the vehicle group.

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