Traumatic Acid,6402-36-4

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Traumatic Acid

CAS No. : 6402-36-4

MCE 国际站：Traumatic Acid

产品活性：Traumatic Acid 是一种伤口愈合剂，也是细胞分裂素 (植物激素)。Traumatic Acid 能增强培养的人类皮肤成纤维细胞的胶原蛋白的生物合成。Traumatic Acid 可抑制 MCF-7 乳腺癌细胞的存活率并增强细胞凋亡和氧化应激。Traumatic Acid 可用于癌症、血液循环系统疾病 (包括动脉高血压)，以及与氧化应激和胶原蛋白生物合成障碍有关的皮肤病的研究。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Apoptosis

In Vitro: Traumatic Acid (0.1, 1 µM; 5 days) significantly increases cell number in fibroblasts.
Traumatic Acid (0.1, 1 µM; 5 days) increases content of GPX activity and reduced glutathione, as well as decreases membrane phospholipid peroxidation in fibroblasts.
Traumatic Acid (0.1, 1 µM; 5 days) enhances the production and secretion of medium collagen in medium of fibroblasts.
Traumatic Acid (100, 200, 400, 600 µM; 48 h) significantly decreases live cell number, especially after 48h treatment at 100µM and 200µM in MCF-7 cells.
Traumatic Acid (50-600 µM; 24, 48 h) causes dose-and time-dependent reduction in cell viability and induces apoptosis in MCF-7 cells.
Traumatic Acid (50-200 µM; 24, 48 h) results in an oxidative damage of protein in MCF-7 cells.
Traumatic Acid (100, 200 µM; 24, 48 h) efficiently enhances oxidative stress level in MCF-7 cells.

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