- ￥1380 - 4200
- MedChemExpress(MCE)
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- HY-101194
- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture
- 英文名：
Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
14325-05-4
- 规格：
5 mg/10 mg/25 mg
| 规格： | 5 mg | 产品价格： | ￥1380.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥2208.0 |
| 规格： | 25 mg | 产品价格： | ￥4200.0 |
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Tin protoporphyrin IX dichloride
CAS No. : 14325-05-4
MCE 国际站：Tin protoporphyrin IX dichloride
产品活性：Tin protoporphyrin IX dichloride (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。Tin protoporphyrin IX dichloride 使 PDAC 管腺癌肿瘤对化疗敏感。
研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
In Vitro: Tin protoporphyrin IX dichloride (20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, Tin protoporphyrin IX dichloride has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.
In Vivo: Tin protoporphyrin IX dichloride (intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.
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文献和实验Bilirubin and Its Carbohydrate Conjugates
In mammals, the open tetrapyrrole bilirubin (structure 2, Fig. 1 ) is the principal degradation product of iron-protoporphyrin-IX (heme). The latter molecule is a tetrapyrrolic macrocycle and plays a critical role in aerobic metabolism
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is the most widely used form of PDT in clinical practice. Topical application of ALA leads to overproduction of the endogenous photosensitizer protoporphyrin IX (PpIX). ALA-PDT
Spectral Analyses of Cytochromes P450
cytochromes, containing protoporphyrin IX as the prosthetic group. Methods are also provided, using alkali and pyridine, for quantitation of the hemoprotein by this prosthetic group. In its oxidized, or ferric state, CYP exists as an equilibrium mixture
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