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货期:询盘
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MedChemExpress LLC
- CAS号:
1059588-19-0
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1 mg/5 mg/10 mg/25 mg/50 mg
| 规格: | 1 mg | 产品价格: | ¥611.0 |
|---|---|---|---|
| 规格: | 5 mg | 产品价格: | ¥1311.0 |
| 规格: | 10 mg | 产品价格: | ¥1940.0 |
| 规格: | 25 mg | 产品价格: | ¥3190.0 |
| 规格: | 50 mg | 产品价格: | ¥4686.0 |
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m-PEG8-Ms
CAS No. : 1059588-19-0
MCE 国际站:m-PEG8-Ms
产品活性:m-PEG8-Ms 是一种 PROTAC 连接桥,属于 PEG 类。m-PEG8-Ms 可用于合成一系列 PROTAC 分子。m-PEG8-Ms 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体活性分子结合物 (ADCs) 的合成。
研究领域:Antibody-drug Conjugate/ADC Related | PROTAC
作用靶点:ADC Linker | PROTAC Linkers
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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文献和实验Aminopeptidases are proteolytic enzymes that remove L -amino acids sequentially from the amino termini of polypeptide chains. A number of aminopeptidases have been isolated, including leucine aminopeptidase from serine kidney cytosol
Crystallization of Kinesin Family Motor Proteins
MgCl2, 2 mM DTT was pre-incubated with 4 mM AMP*PNP or ATP for 2 hoursCrystals grew in 11% PEG 8000, 0.8 M NaCl, 50 mM Na2H2PO4, pH 6.8, 7 mM DTTYun et al., 2003Rat Kinesin-1 rK354Hanging drop Room temperature9-14 mg/ml protein 20 mM PIPES pH 7.5, 50 mM
Buffers: 10 x TE: 100 mM Tris pH 7.5; 10 mM EDTA. 10 x LiAc: 1 M LiAc in H2 O; sterile filter. 50 % PEG 3350: 50 % PEG 3350 in H2 O; sterile filter.
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