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4°C, sealed storage, away from moisture
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货期：1-2天
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MedChemExpress LLC
- CAS号：
132173-07-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3050.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1300.0 |
| 规格： | 5 mg | 产品价格： | ￥2800.0 |
| 规格： | 10 mg | 产品价格： | ￥4400.0 |
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SR-31747
CAS No. : 132173-07-0
MCE 国际站：SR-31747
产品活性：SR-31747 是一种具有免疫抑制和抗炎特性的 sigma 配体。SR-31747 通过抑制固醇异构酶来阻止细胞增殖。
研究领域：Neuronal Signaling
作用靶点：Sigma Receptor
In Vitro: SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner.
In Vivo: In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition.
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文献和实验Isolation of Retroelement from Plant Genomic DNA (PCR法从植物寻找逆
which would refer to another level of classification of retroelements or retrotransposons) 12/7/07: reduced amount of Taq polymerase recommended (we use enzyme from YorkBio, BioLine or Promega - the source of the enzyme does make a difference to the results
Isolation of Retroelement from Plant Genomic DNA (PCR法从植物寻找逆转录元件)
to another level of classification of retroelements or retrotransposons)12/7/07: reduced amount of Taq polymerase recommended (we use enzyme from YorkBio, BioLine or Promega - the source of the enzyme does make a difference to the results). Pseudoviridae ( Ty
的灵敏度、清晰的背景 [ 15 ] ，而且和质谱兼容。 在过去的几年中，一些荧光染料被用来凝胶染色，它们被证明具有较高的灵敏度而且兼容质谱鉴定。这些染料包括商业化的如 Sypros 系列染料，也包括以钌红为主要成分的染料 [ 17~21 ] 。Sypr Ruby ( SR ) 具有与 CCB 相似的一些特征，它是一种发光的钌复合材料，可与蛋白非共价作用。由于染色过程中对氨基酸的修饰是可逆的，所以它与质谱可能会有较好的兼容性[ 17，19] 。另外，尽管 SR 染色饱和度低，但它具有更宽
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