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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
DE-117
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1187451-19-9
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1720.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2500.0 |
| 规格： | 25 mg | 产品价格： | ￥5500.0 |
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Omidenepag isopropyl
CAS No. : 1187451-19-9
MCE 国际站：Omidenepag isopropyl
产品活性：Omidenepag isopropyl 是选择性的，非前列腺素的 EP2 受体激动剂。Omidenepag isopropyl 在角膜穿透过程中转化为活性产品 Omidenepag，Omidenepag 是高度选择性的 EP2 受体激动剂。Omidenepag isopropyl 对 EP1，EP2 和 FP 受体有弱亲和力。Omidenepag isopropyl 可以降低眼内压 (IOP)，有潜力用于青光眼的研究。
研究领域：GPCR/G Protein
作用靶点：Prostaglandin Receptor
In Vivo: Omidenepag isopropyl at 0.0001%, 0.001%, or 0.01%, Xalatan, or vehicle was topically administered to one eye in ocular normotensive monkeys. IOP change after drug administration was compared to the predosing baseline value established on day 1. Omidenepag isopropyl also shows significant and dose-dependent IOP-lowering effects at doses of 0.0001%, 0.001%, and 0.01% in ocular normotensive monkeys, with mean maximal IOP reductions of 2.4 ± 0.6, 7.6 ± 1.7, and 13.3 ± 1.2 mm Hg at each tested concentration, respectively. The significant decreases in IOP for 0.001% and 0.01% OMDI at time 0 of day 7. Omidenepag isopropyl is hydrolyzed in the eye to Omidenepag (OMD), an EP2 receptor agonist , with a significant ocular hypotensive effect in both ocular normotensive and hypertensive animal models.
In ocular hypertensive monkeys finds that Omidenepag isopropyl lowers IOP by increasing both trabecular outflow facility and uveoscleral outflow.
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文献和实验for 10 minutes at room temperature.11. Transfer the upper aqueous layer to a new 1.5 mL tube and add equal volume of isopropyl alcohol.12. Mix well and incubate at -80oC for 12 minutes and spin at 14,000 rpm for 20 minutes at room temperature.13. Dispose
cDNA sequencing based on PCR and random shotgun cloning
and reverse priming sites and the multiple cloning sites of the Stratagene Bluescript vector. These two PCR primers, with the sequence 5'-TCGAGGTCGACGGTATCG-3' for the forward or -16bs primer and 5'-GCCGCTCTAGAACTAG TG-3' for the reverse or +19bs primer
Guidelines for Aseptic Rodent Survival Surgery
(verify within expiration date) - antiseptic scrub (chlorhexadine or equiv.) - isopropyl alcohol -
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