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ATX inhibitor 5
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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
货期:1-2天
MedChemExpress LLC
10 mM * 1 mL/1 mg/5 mg/10 mg
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CAS No. : 2402772-45-4
MCE 国际站:ATX inhibitor 5
产品活性:ATX inhibitor 5 是有效的口服活性 autotaxin (ATX) 抑制剂,IC50 为 15.3 nM。AATX inhibitor 5 具有抗肝纤维化作用,并显着降低 CCl4 诱导的肝纤维化水平。
研究领域:Metabolic Enzyme/Protease
作用靶点:Phosphodiesterase (PDE)
In Vitro: ATX inhibitor 5 (compound 10g) (IC50s=1.21 and 0.78 μM) displays activities against cardiac fibroblasts (CFs) and hepatic stellate cell (HSC).ATX inhibitor 5 at 10 μM successfully suppresses collagen content induced by TGF-β.
In Vivo: ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently.
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