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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1702428-31-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3850.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1750.0 |
| 规格： | 10 mg | 产品价格： | ￥2800.0 |
| 规格： | 25 mg | 产品价格： | ￥5600.0 |
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GSK-3β inhibitor 2
CAS No. : 1702428-31-6
MCE 国际站：GSK-3β inhibitor 2
产品活性：GSK-3β inhibitor 2 (Compound 3) 是一种有效，选择性和口服活性的 GSK-3β 抑制剂，IC50 为 1.1 nM。GSK-3β inhibitor 2 可以穿越血脑屏障。GSK-3β inhibitor 2 有用于阿尔茨海默氏病的潜力。
研究领域：PI3K/Akt/mTOR | Stem Cell/Wnt
作用靶点：GSK-3
In Vitro: The pyridine carboxamide of GSK-3β inhibitor 2 (Compound 3) makes hydrogen bonds with the hinge V135 backbone amide, and the carbonyl oxygen of the thiazolyl primary amide formed a critical hydrogen bond with K85. The quality of the electron density for the methyl group of the methoxy moiety in GSK-3β inhibitor 2 does not allow its unambiguous placement in the model, but a small molecule crystal structure of GSK-3β inhibitor 2 determined by single crystal X-ray diffraction method confirmed the intramolecular hydrogen bonding between the methoxy -O- and the amide N-H in GSK-3β inhibitor 2.
In Vivo: The elevation of hyperphosphorylated Tau (pTau) is mimicked in LaFerla 3xTg-C57BL6 mice, and accordingly, these mice are used as an in vivo model of Alzheimer’s disease. GSK-3β inhibitor 2 (Compound 3) shows a significant reduction in pTau396 when administered orally at 30 mg/kg as a nanosuspension to LaFerla 3xTg-C57BL6 male mice. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26) as determined as a single time point.
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文献和实验This chapter introduces a new method of maintaining human embryonic stem cells (hESCs) in the undifferentiated state through treatment with a GSK-3 inhibitor, BIO, under a feeder-free condition. Additionally, methods are introduced that determine
A Conformationally Restricted -Strand HIV Protease Inhibitor
after the potent HIV protease inhibitor 2 , which together with a series of related derivatives was developed at Abbott Laboratories ( 11 ). This pseudopeptide contains a symmetrical diamino diol motif 8 (Fig. 2 ) flanked by Cbz-protected valine residues
又称β-D-葡糖苷醛酸酶。是作用于 D-葡糖醛酸的β -配糖体，使其葡糖醛酸苷键加水分解的酶的总称。 EC． 3． 2． 1． 31．在实验室中，为测定方便起见，在酚酞等游离后，是使用以容易比色定量的具有配质的葡糖醛酸苷为基质的方法。但因该酶对配质的特异性甚广，也能作用于以醇、类固醇、羧酸等为配质的β -D-葡糖醛酸苷。因酶来源不同而有相当大的差异。天然基质（真基质）到底如何，有时也不一定很清楚。高等植物、微生物中虽也有存在，但在动物中，该酶却几乎存在于所有的组织中，除了血浆等体液中常
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