PS210,1221962-86-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

PS210

CAS No. : 1221962-86-2

MCE 国际站：PS210

产品活性：PS210 是一种针对 PDK1 的 PIF 结合口袋的有效且选择性的 PDK1 激活剂。PS210 对其他蛋白激酶 (包括 PDK1 下游信号传导成分，如 S6K，PKB/Akt 或 GSK3) 无活性。在细胞中，PS210 的前药 PS423 可作为 PDK1 的底物选择性抑制剂，抑制 S6K 的磷酸化和活化。

研究领域：PI3K/Akt/mTOR

作用靶点：PDK-1

In Vitro: When PS210 induces a stabilization of PDK1 to the temperature gradien, PS210 stabilized the residue Arg131, located opposite to the helix a-B at the other extreme of the helix a-C. Thus, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Glucose Metabolism Compound Library  |  Highly Selective Activators Library  |  BX795  |  GSK2334470  |  Polyphyllin I  |  BX-912  |  MP7  |  BX517  |  OSU-03012  |  PS48  |  (R)-PS210  |  PDK1-IN-RS2  |  BX-320  |  PS47  |  CRTh2 antagonist 3  |  LDHA/PDKs-IN-1  |  LDHA/PDKs-IN-2  |  PDKtide  |  PKD-IN-1 dihydrochloride  |  PKM2 activator 6  |  PKM2/PDK1-IN-1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds