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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
941575-71-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥848.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥395.0 |
| 规格： | 5 mg | 产品价格： | ￥915.0 |
| 规格： | 10 mg | 产品价格： | ￥1475.0 |
| 规格： | 25 mg | 产品价格： | ￥2913.0 |
| 规格： | 50 mg | 产品价格： | ￥4163.0 |
| 规格： | 100 mg | 产品价格： | ￥5825.0 |
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BIP-135
CAS No. : 941575-71-9
MCE 国际站：BIP-135
产品活性：BIP-135 是一个高效、选择性的，ATP 竞争性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 作用的IC50 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。
研究领域：PI3K/Akt/mTOR | Stem Cell/Wnt
作用靶点：GSK-3
In Vitro: BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress.
In Vivo: BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy.
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文献和实验CD43 分子 CD43 常用单克隆抗体或代号： OTH71C5,G19- 1;(Leukosialin,Sialophorin) 主要表达细胞： T,G,M [NL] 分子质量(kDa)和结构： gp95- 135 功 能： T细胞活化、增殖和粘附,与CD54结合 CD43 Aka leukosialin, sialophorin Appears
）。其中消化性溃疡手术后者Hp阳性检出率为48.2%(65/135),胃癌手术后者Hp阳性检出率为47.1%(8/17),二者差异无显著性(P>0.05)；毕氏Ⅰ式术后残胃炎组，Hp阳性检出率为55.6%（45/81）；而毕氏Ⅱ式术后残胃炎组，Hp阳性检出率为37.0%（20/54），二者有显著性差异（P 表1 治疗后各型残胃炎的变化 诊断 Hp阴转 粘膜炎症 好转（%） 吻合溃疡 愈合（%） 胆汁返流 消失（%） 残胃炎+吻合口炎 71.4 100.0
31 24 21 18 15 13 11 10 1550 440 220 135 92 68 52 41 34 28 23 21 18 15 15 910 250 120 71 48 34 26 21 17 14 12
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