This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to a region of human Cytokeratin-7.
Gene ID
3855
SwissProt
P08729
Synonyms
K7; CK7; SCL; K2C7
Category
Cytoskeletal Signaling
Background
Keratin-7 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. Keratin-7 is found in simple glandular epithelia, and in transitional epithelium. Epithelial cells of the lung and breast both contain keratin-7, but some other glandular epithelia, such as those of the colon and prostate, do not. Because the keratin-7 antigen is found in both healthy and neoplastic cells, antibodies to CK7 can be used in immunohistochemistry to distinguish ovarian and transitional cell carcinomas from colonic and prostate cancers, respectively.