Complement Classical Pathway E

Evaluation of Complement Function by ELISA

chapter describes the methodology of ELISA assays for assessment of the classical pathway, the alternative pathway, the MBL-dependent lectin pathway, and the Ficolin-3-dependent lectin pathway of complement in clinical laboratory diagnostics.

Classical Complement Pathway Components C1r and C1s: Purification from Human Serum and in Recombinant Form and Functional Characterization

C1r and C1s are the proteases responsible for the activation and proteolytic activity of the C1 complex of the classical complement pathway, respectively. They are assembled into a Ca2+ -dependent C1s–C1r–C1r–C1s tetramer which in turn

The Complement System:An Overview

Fig. 1.  The complement system and its control. The constituent pathways of the C system and the component proteins are shown. Enzymatic cleavages are represented by thick arrows. The lectin pathway differs from the CP only in that the MBP-MASP