大家都在搜
手机验证
50
A83-01 (ALK5抑制剂)
一年
上海信裕生物科技有限公司
-20℃保存,至少一年有效。5mg和25mg包装也可室温保存,至少6个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。
10mM;5mg;25mg
化学信息:
化学名 | 3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide | |
简称 | A83-01 | |
别名 | A 83-01, A-83-01, ALK5 Inhibitor IV | |
中文名 | N/A | |
化学式 | C25H19N5S | |
分子量 | 421.52 | |
CAS号 | 909910-43-6 | |
纯度 | 98% | |
溶剂/溶解度 | Water<1mg/ml; DMSO21mg/ml; Ethanol<1mg/ml | |
溶液配制 | 5mg加入1.19ml DMSO,或者每4.22mg加入1ml DMSO,配制成10mM溶液。SF7917-10mM用DMSO配制。 |
生物信息:
产品描述 | A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5nM respectively). | ||||
信号通路 | TGF-beta/Smad | ||||
靶点 | ALK5 | - | - | - | - |
IC50 | 12nM | - | - | - | - |
体外研究 | A-83-01, an inhibitor of TGF-β type I receptor, increased the expression of Myf5 and MyoD, and enhanced myotube formation. Microarray analysis of HM-1 cells treated with TGF-β1 and/or A-83-01 revealed that A-83-01 efficiently inhibited transcriptional changes that are induced by TGF-β1. -83-01 treatment significantly increased these parameters within 24h that was positively related to pericyte coverage and tumor cell proliferation. Furthermore, apparent diffusion coefficient (ADC) determined by diffusion-weighed imaging was decreased by A-83-01 treatment, suggesting the decrease of tumor interstitial fluid pressure. Vascular function of the tumor improved by A-83-01treatment well assessed on post-Gd-L-enhanced MR images. | ||||
体内研究 | The targeting efficacy of single intravenous injections of F-SL combined with A-83-01 was evaluated by measurement of the biodistribution and the antitumor effect in mice bearing murine lung carcinoma M109. A-83-01 temporarily changed the tumor vasculature around 3h post injection. A-83-01 induced 1.7-fold higher drug accumulation of F-SL in the tumor than liposome alone at 24h post injection. | ||||
临床实验 | N/A | ||||
特征 | N/A |
相关实验数据(此数据来自于公开文献,信裕生物并不保证其有效性):
酶活性检测实验 | |
方法 | N/A |
细胞实验 | |
细胞系 | N/A |
浓度 | N/A |
处理时间 | N/A |
方法 | N/A |
动物实验 | |
动物模型 | N/A |
配制 | N/A |
剂量 | N/A |
给药方式 | N/A |
产品编号 | 产品名称 | 包装 |
XY-7917-10mM | A83-01 (ALK5抑制剂) | 10mM×0.2ml |
XY-7917-5mg | A83-01 (ALK5抑制剂) | 5mg |
XY-7917-25mg | A83-01 (ALK5抑制剂) | 25mg |
— | 说明书 | 1份 |
保存条件:
-20℃保存,至少一年有效。5mg和25mg包装也可室温保存,至少6个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。